Drea de Matteo 1973 Január 17-én született. New York Queens nevű városrészén. Teljes neve Andrea Donna de Matteo. Drea befejezte New York-i Scool of the Art nevű iskolát, diplomával. Két kutyájával és két macskájval él az East Village-en. Drea ismert lett az HBO-n lévő "The Sopranos" sikersorozat által, és évekig a maffiózó Christopher barátnőjét játszotta. Amikor a "Joey" aláírta, hívták a "The Sopranos"-ba játszani. De a karakterét a végén meggyilkolták. A meglepetés erejét elveszítette volna, a sajtó értehtő módon rosszúl volt informálva. Drea fellépett néhány független filmben, mielött 2001-ben "Swordfish"-ben John Travolta és Haalle Berry oldalán volt látható.

TV-sorozatok

2004-2005 Joey - Szerep: Gina Tribbiani

1999-2005 The Sopranos (75 rész) - szerep: Adriana La Cerva (Nicht in jeder Folge)

Mozi és TV filmek:

2003 Beacon Hill

2003 Dirty Love

2003 Prey for Rock & Roll

2002 Deuces Wild

2002 Love Rome

2002 The Perfect You

2001 Swordfish

2001 'R Xmas

2000 The Gentleman from Boston

2000 Sleepwalk

1999 Meet Prince Charming

1996 'M' Word

Fellépések Tv- és Talkshowkban::

2004 Late Show with David Letterman

2004 The View (Somers/de Matteo)

2003 The Greatest - 100 Greatest Songs of the past 25 Years (Vendéglátó)

2002 VH1 Big in 2002 Awards (Vendéglátó)

2002 Late Show with David Letterman

Emmy Award winner Drea de Matteo, who plays the role of Gina, Joey’s sister, has charmed America as Adriana, Christopher’s loyal and loving fiancée on HBO’s critically acclaimed “The Sopranos,” and is currently in production on Focus Features’ “Assault on Precinct 13,” a remake of John Carpenter’s 1976 thriller.

De Matteo is also currently developing the feature film “The Waylon Jennings Tribute” which she will direct and produce. Similar to “The Last Waltz,” the film will focus on a huge concert.

De Matteo was most recently seen on the big screen co-starring with Gina Gershon in “Prey for Rock n’ Roll” directed by Alex Steyermark. Her other feature films include Warner Bros.’ “Swordfish” and Abel Ferrara’s “R’Xmas.”
As if acting wasn't enough, de Matteo co-owns the ultra hip East Village boutique Filth Mart.

During her downtime, de Matteo always returns to HB Studios where her mother has taught playwriting for over 25 years. She and her partner Robin Whitehouse devote a lot of time to the studio and their company, Great Dane Productions, as they find new writers and projects as well as working on their own material. In fact, right after “Joey” wraps production this year, de Matteo will head back to New York to star in a play her mother scripted entitled "The Heart Transplant."

De Matteo has a bachelor of fine arts degree from New York University’s Tisch School of the Arts in film production. She currently lives in New York and her birthday is January 19.